Forkhead box C1 (FOXC1) is a transcription factor that plays an important role in a wide variety of biological processes, including development, cell differentiation, proliferation, and tissue-specific gene regulation. The FOXC1 luciferase reporter vector is designed to study the transcriptional activity of FOXC1. The vector contains a FOXC1 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report FOXC1 activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.