Macrophage Inflammatory Proteins (MIP) is a member of the C-C subfamily of chemokines that exhibit a variety of proinflammatory activities in vitro including leukocyte chemotaxis. There are two major forms, MIP-1α and MIP-1β, in humans. They are major factors produced by macrophages after stimulated with bacterial endotoxins. They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as IL-1, IL-6 and TNFα from fibroblasts and macrophages. In addition to its proinflammatory activities, MIP-1α inhibits the proliferation of hematopoietic stem cells in vitro and in vivo.
 
Detection Range:
    16 - 1000 pg/mL
Sensitivity:
    8 pg/mL