The glucocorticoid receptor (GR) is a nuclear receptor that mediates the cellular effects of glucocorticoid hormones like cortisol. The GR luciferase reporter vector is designed to study the transcriptional activity of this receptor. The vector contains a GR DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report GR activity while maintaining a low basal level of transcription.
 
The inclusion of a hygromycin resistance gene in the vector allows it to be used for stable cell line selection. Additionally, a GFP-tagged version of the vector is available for monitoring transfection efficiency. Maps of the vector, including hygromycin and GFP configurations, can be found in the product's image gallery.