TEA domain transcription factor 1 (TEAD1) is a transcription factor that plays a significant role in the Hippo signaling pathway and regulates gene expression involved in cell growth, differentiation, and tissue homeostasis. The TEAD1 luciferase reporter vector is designed to study the transcriptional activity of TEAD1. The vector contains a TEAD1 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report TEAD1 activity while maintaining a low basal level of transcription.