Yin Yang 1 (YY1) is a zinc-finger transcription factor that plays a pivotal role in regulating various cellular processes, including gene expression, cell growth, development, differentiation, and immune responses. The YY1 luciferase reporter vector is designed to study the transcriptional activity of YY1. The vector contains a YY1 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report YY1 activity while maintaining a low basal level of transcription.