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CRISPR-Cas9 

A complete suite of CRISPR-Cas9 tools and systems for gene editing, functional genomics, and pathway analysis—designed to support every stage of your genome engineering workflow.

Principle 

The CRISPR-Cas9 system harnesses a programmable RNA-guided nuclease to introduce precise double-stranded breaks at specific genomic loci, enabling targeted gene knockout, modification, or regulation. By combining this powerful genome editing tool with specialized vectors, reporter systems, and screening kits, our products provide researchers with flexible and efficient solutions to dissect gene function, analyze signaling pathways, and accelerate therapeutic discovery.

Product Categories

Cas9-U6/H1 DualGuide Knockout Vectors

Signosis offers a comprehensive suite of Cas9-U6/H1 DualGuide Knockout Vectors, featuring a single-plasmid design and dual-promoter sgRNA expression, optimized for enhanced knockout efficiency and targeting pathway regulators, kinases, and receptors with increased reliability.

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CRISPR-Cas9 sgRNA In Vitro Screening Kit

Signosis offers a CRISPR-Cas9 sgRNA in vitro screening kit to produce sgRNA via in vitro transcription, test sgRNA function, and evaluate editing efficiency—helping you optimize CRISPR editing both before and after cell transfection.

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CRISPR Knockout with TF Reporter Cell Lines System

Signosis offers 80+ stable TF reporter cell lines (e.g., NRF2, NFκB, p53) plus CRISPR knockout plasmids targeting key regulators. These reporter lines provide easy readouts to assess knockout effects.

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Benefits

Comprehensive Toolkit

Access a full range of CRISPR-Cas9 products, from all-in-one knockout vectors to specialized reporter cell lines and screening kits, that covers every step of your gene editing workflow.

High Precision and Efficiency

Utilize optimized systems designed to deliver accurate, efficient, and reproducible gene editing results across diverse cell types and experimental settings.

Ready-to-Use

Simplify your experiments with ready-to-use products that reduce cloning, transfection, and screening time.

Applications Across Fields

Ideal for functional genomics, pathway discovery, drug target validation, and therapeutic development.

Flexible Experimental Design

Tailor your approach with customizable sgRNA options, various reporter lines, and screening tools to suit specific research goals.

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