p53 is a transcription factor that acts as a tumor suppressor, and regulates the cell cycle, apoptosis, DNA repair, and senescence. The p53 luciferase reporter vector is designed to study the transcriptional activity of p53. The vector contains a p53 DNA consensus binding site and TA minimal promoter upstream of a firefly luciferase reporter gene, which can specifically report p53 activity while maintaining a low basal level of transcription.