8-Iso-Prostaglandin F2α (8-iso-PGF2α) is a key biomarker of lipid peroxidation and oxidative stress. It forms when reactive oxygen species oxidize arachidonic acid in cell membranes, producing F2-isoprostanes. Elevated 8-iso-PGF2α levels indicate oxidative damage to lipids, reflecting cellular and systemic oxidative burden. Because lipid peroxidation contributes to cardiovascular disease, neurodegeneration, and inflammation, monitoring 8-iso-PGF2α offers valuable insight into oxidative injury and the effectiveness of antioxidant defenses.
 
Signosis' 8-iso-PGF2α ELISA Kit utilizes a competitive ELISA assay to measure 8-iso-PGF2α levels in samples.