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Colorful Disks

Parental Cell Lines

Signosis offers some of the parental (Host) cells used for generating its stable cell lines. These cell lines can be used as a matched control for their related stable cell lines. All cell lines tested negative for mycoplasma.

Principle

A parental cell line is a group of cells that are derived from the same source or organism and are used as a starting point for creating different cell lines. Parental cell lines are often used in biomedical research and drug development to establish a baseline or control group for comparison purposes.

Parental cell lines can also be used to produce biologics, such as monoclonal antibodies or recombinant proteins, which are used as therapeutics. In this case, the parental cell line serves as the foundation for the production of these products.

HEK293 Parental Cell 
HEK293.JPG

Benefits

Cell Lines

HeLa 
HEK293 
A549
NIH/3T3 


 

Jurkat 
K562 
COS-7
MCF7 


 

Research Application

HeLa cells are a commonly used cell line in cancer research, derived from cervical cancer cells. They are an immortal cell line, meaning they can divide indefinitely. HeLa cells have been extensively studied and used in many different research applications due to their rapid growth, adaptability, and ability to easily transfect with exogenous DNA.

 

Research applications:

  • Studying the mechanisms of cancer development and progression.

  • Screening for novel cancer therapies.

  • Evaluating the efficacy of various cancer treatments, such as chemotherapy, radiation, and immunotherapy.

  • Investigating the effects of viral infections, such as HPV, on cancer development.

  • Studying the regulation of cell cycle and apoptosis.

HEK293 cells are a widely used human embryonic kidney cell line. They are also an immortal cell line and can be easily transfected with exogenous DNA. HEK293 cells have been extensively used in research for protein expression and biochemical studies due to their high transfection efficiency and robust protein expression.

Research applications:

  • Protein expression and purification for biochemical and structural studies.

  • Studying signaling pathways and protein-protein interactions.

  • Developing recombinant viral vectors for gene therapy.

  • Developing and optimizing cell-based assays for drug screening.

  • Studying the effects of gene mutations on protein function.

A549 cells are a human lung carcinoma cell line commonly used in respiratory research. They were originally isolated from a patient with adenocarcinoma and have been extensively studied for their ability to differentiate into respiratory epithelial cells.

 

Research applications:

  • Studying respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer.

  • Investigating the effects of environmental toxins, such as cigarette smoke, on lung function.

  • Developing and optimizing cell-based assays for drug screening.

  • Studying the regulation of inflammation and immune response in the respiratory system.

  • Studying the mechanisms of viral infections, such as influenza and respiratory syncytial virus (RSV).

NIH/3T3 cells are a mouse embryonic fibroblast cell line. They are widely used in research for their ability to rapidly divide and their ease of transfection with exogenous DNA.

Research applications:

  • Studying the regulation of cell cycle and apoptosis.

  • Studying the effects of gene mutations on protein function.

  • Developing and optimizing cell-based assays for drug screening.

  • Studying the mechanisms of cancer development and progression.

  • Studying the regulation of cellular metabolism and energy production.

Jurkat cells are a human T lymphocyte cell line commonly used in immunology research. They were originally isolated from a patient with acute T cell leukemia and have been extensively studied for their role in immune function.

Research applications:

  • Studying the regulation of immune function, including T cell activation, differentiation, and apoptosis.

  • Studying the mechanisms of immune-related diseases, such as autoimmune disorders and cancer.

  • Developing and optimizing cell-based assays for drug screening.

  • Studying the effects of gene mutations on immune function.

  • Studying the regulation of cellular metabolism in immune cells.

K562 cells are a human erythroleukemia cell line commonly used in cancer research. They were originally isolated from a patient with chronic myelogenous leukemia and have been extensively studied for their role in erythropoiesis and differentiation.

Research applications:

  • Studying the regulation of erythropoiesis and differentiation.

  • Studying the mechanisms of cancer development and progression.

  • Developing and optimizing cell-based assays for drug screening.

  • Studying the effects of gene mutations on protein function.

  • Studying the regulation of cellular

COS-7 is a cell line derived from the African green monkey kidney cells, commonly used in molecular biology and biotechnology research. The cells are highly transfectable, allowing for the introduction of exogenous genes and expression of recombinant proteins.

Research applications:

  1. Protein expression and purification: COS-7 cells are commonly used for the production of recombinant proteins due to their high transfection efficiency and ability to express high levels of proteins.

  2. Gene expression studies: COS-7 cells are often used to study the function and regulation of genes, as they can be easily transfected with plasmids containing reporter genes and other genetic constructs.

  3. Viral vector production: The high transfection efficiency of COS-7 cells makes them useful for the production of viral vectors for gene therapy and other applications.

  4. Drug discovery: COS-7 cells can be used in high-throughput screening assays to identify potential drug candidates for various diseases.

MCF7 is a breast cancer cell line derived from a human patient with metastatic breast adenocarcinoma. The cells are widely used in breast cancer research as a model system for studying the molecular mechanisms underlying the disease.

Research applications: 

  1. Breast cancer biology: MCF7 cells are used to study various aspects of breast cancer biology, including the mechanisms of tumor progression, drug resistance, and metastasis.

  2. Drug discovery: MCF7 cells are used in drug discovery research to screen for potential therapeutic compounds that may be effective in treating breast cancer.

  3. Hormone receptor signaling: MCF7 cells express estrogen receptors and are used as a model system to study the mechanisms of hormone receptor signaling in breast cancer.

  4. Gene expression studies: MCF7 cells are commonly used to study the expression and regulation of genes associated with breast cancer.

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